Chauhan Devesh
India
Review Article
Spirulina Reverses Histomorphological Changes in Diabetic Osteoporosis in Pioglitazone Treated Rats
Author(s): Chauhan Devesh, Mehla Kritika, Nair Anroop, Sehajpal Prabodh Kumar and Gupta SumeetChauhan Devesh, Mehla Kritika, Nair Anroop, Sehajpal Prabodh Kumar and Gupta Sumeet
Aim: The study was undertaken to assess the protective effect of Spirulina fusiform on risk fracture of bone in insulin resistance rat model and pharmacodynamics effects of Pioglitazone with Spirulina in treating hyperglycemia and hyperlipidaemia of insulin resistance rat.
Method: For this aim, 30 Wistar albino rats were equally divided into five groups as control (NC), diabetes mellitus (DM), diabetes mellitus + Pioglitazone (DM+P), diabetes mellitus + Spirulina (DM+S), and diabetes mellitus + Pioglitazone + Spirulina (DM+P+S). Serum glucose, Triglyceride, HDL, LDL and insulin concentrations were estimated by standard methods in blood samples collected on 21st day. Morphological changes in pancreas and microarchitectual structure in femur bone were observed by histopathology studies.
Results: A significant decrease in bone thickness was observed in Diabetes Mellit.. View More»
