Cardiovascular Pharmacology: Open Access

Chen-Fuh Lam

Publications

• Research Article
  Effects of Glucagon-Like Peptide-1 on Arteriovenous Fistula Remodelling and Vascular Smooth Muscle Cell Phenotype Switching in Diabetic Rats
  Author(s): Jun-Neng Roan, Wei-Kung Tseng, Chwan-Yau Luo, Ping-Chia Li, Wei-Hung Lin, Yau-Sheng Tsai and Chen-Fuh LamJun-Neng Roan, Wei-Kung Tseng, Chwan-Yau Luo, Ping-Chia Li, Wei-Hung Lin, Yau-Sheng Tsai and Chen-Fuh Lam
  
  This study aimed to determine the potential vascular protective effect of exendin-4, a synthetic glucagonlike peptide (GLP)-1 analogue, on the blood flow and remodelling of arteriovenous (AV) fistulas in a rat model of diabetes. AV fistulas were created in Sprague-Dawley rats with streptozotocin-induced diabetes. The animals were then randomly assigned to receive an intraperitoneal injection of vehicle (saline) or exendin-4 for about 2 weeks. The blood flow and vasomotor function of the aortic limb of the fistula were measured. Concentrations of serum norepinephrine and its associated tissue signal proteins, and vascular smooth muscle cell (VSMC) contractile proteins, matrix metalloproteinase (MMP)-2, and collagen expression in the remodelled aorta were examined. Exendin-4 attenuated the contraction response to phenylephrine in isolated arterial segments from treated animals. Treatmen.. View More»
  DOI: 10.4172/2329-6607.1000169

  Abstract PDF