Christian Cadeddu
Department of Medical Sciences “M Aresu”,
Strada Statale 554, Km 4.500, 09042 Monserrato (Cagliari)
Italy
Research Article
Early Ventricular Dysfunction in Type II Diabetes: Role of Metabolic Unbalance
Author(s): Christian Cadeddu, Silvio Nocco, Davide Piano, Martino Deidda, Efisio Cossu, Marco Giorgio Baroni and Guseppe MercuroChristian Cadeddu, Silvio Nocco, Davide Piano, Martino Deidda, Efisio Cossu, Marco Giorgio Baroni and Guseppe Mercuro
Introduction: Diabetic cardiomyopathy is characterized by early myocardial systolic and diastolic impairment. Many studies have highlighted reduced contractile reserve in patients affected by Metabolic Syndrome (MS) and in the early stages of diabetes mellitus, however, it has not been confirmed by all the authors. A conclusive hypothesis on the basis of this early myocardial dysfunction needs to be ascertained.
Methods: Forty patients: 20 (age 59 ± 7 years) with type II diabetes, diagnosed at least 5 years earlier and treated with insulin sensitizers, 20 with MS (WHO definition; age 57 ± 10 years), and 20 age- and sex-matched healthy controls were studied. MS patients with elevated insulin resistance (HOMA-IR >2.8), but no arterial hypertension with evidence of cardiac hypertrophy, were selected. In order to exclude ischemic heart disease and to evaluate left.. View More»
