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Dimitra Tripolitsioti
Dimitra Tripolitsioti
Switzerland
Publications
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Review Article
The Ser/Thr Kinase MAP4K4 Controls Pro-Metastatic Cell Functions
Author(s): Dimitra Tripolitsioti, Michael A Grotzer and Martin BaumgartnerDimitra Tripolitsioti, Michael A Grotzer and Martin Baumgartner
The search for novel targeted therapies for major human conditions such as diabetes, cardiovascular diseases and cancer is a slow and costly process. Progress is often hampered by poor drug efficaciousness in the patients, low selectivity/specificity of the compounds and cellular evasion mechanism that are rather common in anti-cancer therapies. This is particularly true also for compounds inhibiting kinases, which in theory are optimal targets thanks to their druggable enzymatic activity. Novel targeting strategies are needed to reduce side effects and treatment failure caused by non-specific drug function and target resistance, respectively. An ideal compound will repress the relevant kinase effector function, while leaving kinase functions that are not disease-relevant unaltered. To achieve function-specific inhibition, the molecular mechanism of the drug target that governs the pa.. View More»
DOI: 10.4172/2157-2518.1000284