Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
+44 1223 790975
ISSN: 2155-9899
+44 1223 790975
Dimitri Poddighe
Azienda Ospedaliera di Melegnano,
Milan
Italy
Case Report
Pediatric Systemic Lupus Erythematosus (SLE) As an Onset of Common Variable Immunodeficiency (CVID): The Double Link between Immunodeficiency and Autoimmunity
Author(s): Dimitri Poddighe, Fabio Pagella, Amelia Licari and Gian Luigi MarsegliaDimitri Poddighe, Fabio Pagella, Amelia Licari and Gian Luigi Marseglia
Recurrent, unusual and complicated infections are the hallmark of immunodeficiency. Primary Immunodeficiency (PID) is caused by a genetic defect impairing the immune response. Common Variable Immunodeficiency (CVID) is classified as a primary immunodeficiency with prevalent antibody defect, manifesting with respiratory and gastrointestinal infections. However, CVID is characterized by an increased prevalence of autoimmune diseases too. Here, we describe a child presenting an abnormal pattern of infections and autoimmune phenomena, fulfilling diagnostic criteria for systemic lupus erythematosus (SLE). No classified PID could be demonstrated for several years, until she developed an antibody deficiency much later than the onset of the aforementioned clinical issues. Actually, a deficit of B memory cells, being useful to classify CVID after the diagnosis.. View More»
DOI:
10.4172/2155-9899.1000267