Advanced Techniques in Biology & Medicine
Open Access
ISSN: 2379-1764
+44 1223 790975
ISSN: 2379-1764
+44 1223 790975
Elisangela de Paula Silveira-Lacerda
Universidade Federal de Goiás, CEP: 74690-900, Goiânia/GO
Brazil
Research Article
Investigation of Gluthatione S-Transferase Variants in a Healthy Population in Goiânia-Go
Author(s): Lucas Carlos Gomes Pereira, Nádia Aparecida Bérgamo, Angela Adamski da Silva Reis, Carlos Eduardo Anunciação and Elisangela de Paula Silveira-LacerdaLucas Carlos Gomes Pereira, Nádia Aparecida Bérgamo, Angela Adamski da Silva Reis, Carlos Eduardo Anunciação and Elisangela de Paula Silveira-Lacerda
Genetic polymorphisms in glutathione S-transferases (GSTs) genes might influence the detoxification activities of the enzymes predisposing individuals to a lot of disiases. Owing to the presence of these genetic variants, inter-individual and ethnic differences in GSTs detoxification capacity have been observed in various populations. Therefore, the present study was performed to determine the prevalence GSTM1*0/*0, GSTT1*0/*0 and GSTP1 Ile105Val polymorphisms in 100 healthy individuals from Goiânia - GO. GSTM1 and GSTT1 polymorphisms were analyzed by a Multiplex-PCR approach, whereas GSTP1 polymorphisms were examined by PCR-RFLP. The frequencies of GSTM1 and GSTT1 *0/*0 genotypes are 49% and 31%, respectively. The frequencies of GSTP1 Ile/Ile, Ile/Val and Val/Val genotypes were 40%, 53% and 7%, respectively. The wild-type (Ile) and variant (Val) allele frequencies were 66.5% an.. View More»
DOI:
10.4172/2379-1764.1000256