Journal of Infectious Diseases & Preventive Medicine
Open Access
ISSN: 2329-8731
ISSN: 2329-8731
Eltahir AG Eltahir
Institute of Endemic Diseases,
Sudan
Research Article
Drug Resistant Mycobacterium tuberculosis Complex Isolates among Patients with Tuberculous Lymphadenitis
Author(s): Nagat Ibrahim Elhag, Eltahir AG Eltahir, Ahamed Mohamed Elhassan, Ahamed Modawi Musa, Alfatih Aljaafarie, Sara Hassab Algawi and Omima Abed AzizNagat Ibrahim Elhag, Eltahir AG Eltahir, Ahamed Mohamed Elhassan, Ahamed Modawi Musa, Alfatih Aljaafarie, Sara Hassab Algawi and Omima Abed Aziz
Objectives: Seventy five patients with lymphadenopathy who were referred to the Clinic of Lymphadenopathy at the Institute of Endemic Diseases, University of Khartoum were enrolled in our study to detect gene mutation that associated with drug resistance to streptomycin and rifampicin.
Materials and methods: Seventy five patients of lymphadenopathy were enrolled for Fine needle aspiration cytology and polymerase chain reaction (PCR). PCR-single strand confirmation polymorphism (PCR-SSCP) for gene mutation was used to detect gene mutation for tuberculous lymphadenitis group.
Results: Cytomorphologically, thirty cases showed necrotizing granulomatous tuberculous lymphadenitis (40%) while twenty cases (26%) showed reactive lymph nodes changes. The remaining twenty five cases (34%) had secondary lymph nodes deposits. A.. View More»
DOI:
10.4172/2329-8731.1000130