School of Basic Medicine, Hebei University of Traditional Chinese Medicine,
326, Xinshi South Road, Shijiazhuang 050091, Hebei
IR Iran
Review Article
The Nervous Mechanism of Sympathetic over Activity Induced by Chronic Intermittent Hypoxia
Author(s): Qi An and En-Sheng JiQi An and En-Sheng Ji
Hypertension is concerned to be a common complication in Chronic Intermittent Hypoxia (CIH) conditions which mimic the state of Obstructive Sleep Apnoea (OSA) in clinic. Sympathoexcitation is a crucial origin in the process of high blood pressure and the mechanisms involved in the sympathoexicitatory changes after CIH exposure are complex referring to chemoreflex, baroreflex, neurotransmitters, and central nuclei and so on. In this review we predominantly expound the effect of CIH-induced potentiated Carotid Body (CB) chemoreceptor sensitivity to hypoxia stimulation which results in the enhancement of RSNA and Endothelin (ET) is mentioned due to its expression in CB and the fact that ET is thought to be a significant chemoreceptor-excitatory transmitter. Previously studies have shown expression of ET and ET receptors in the CB chemoreceptor glomus cells and vessel sys.. Read More»
Pulmonary & Respiratory Medicine received 1690 citations as per Google Scholar report
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