Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
+44 1223 790975
ISSN: 2155-9899
+44 1223 790975
Fekadu Abebe
Institute for Health and Society, Department of Community Medicine,
1130 Blindern, 0318 Oslo
Norway
Review Article
The Role of T cells In Mucosal Immunity against Mycobacterium tuberculosis (Mtb) Infection: A Review of Current Understanding
Author(s): Fekadu AbebeFekadu Abebe
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) remains one of the most important infectious diseases globally. Because Bacille Calmette-Guerin (BCG) vaccine is short of preventing transmission, the search for an efficacious vaccine to either augment that of BCG or to replace has been intensified globally. Currently, there are many candidate vaccines in different stages of clinical trials but none of these has achieved the desired efficacy to control TB. One central issue in TB immunology is lack of clear understanding as to what leads to immune protection or development of clinical disease. Tuberculosis is primarily a disease of the lungs and the main portal of entry of Mtb to the lungs and systemic organs is the respiratory tract and its mucosal surfaces. Therefore, the role of mucosal immunity against Mtb infection has been the subje.. View More»
DOI:
10.4172/2155-9899.1000254