Journal of Liver

Gaetan Van Simaeys

Publications

• Research Article
  Dynamic Molecular Imaging for Hepatic Function Assessment in Mice: Evaluation in Endotoxin-Induced and Warm Ischemia-Reperfusion Models of Acute Liver Failure
  Author(s): Félicie Sherer, Gaetan Van Simaeys, Jesper Kers, Qing Yuan, Gilles Doumont, Marie-Aline Laute, Cindy Peleman, Dominique Egrise, Tony Lahoutte, Véronique Flamand and Serge GoldmanFélicie Sherer, Gaetan Van Simaeys, Jesper Kers, Qing Yuan, Gilles Doumont, Marie-Aline Laute, Cindy Peleman, Dominique Egrise, Tony Lahoutte, Véronique Flamand and Serge Goldman
  
  Background: In hepatic transplantation, inflammatory response related to liver ischemia-reperfusion injury is an important cause of hepatocellular damage that may lead to organ dysfunction. This project aims to develop a new method of dynamic imaging for the local analysis of hepatic function using un-metabolized 99mTc-labeled mebrofenin excretion time in the bile canaliculi as a read-out. Methods: C57BL/6 female mice underwent acute liver damage induced either by endotoxin administration or by warm ischemia-reperfusion. Liver damage intensity was assessed with a 99mTc-labeled mebrofenin dynamic planar imaging protocol, together with biological parameters of liver damage — levels of blood transaminases, liver necrosis and neutrophil infiltration. The acquisition data consisted of a series of 60-frame pinhole images performed on a gamma camera. A region of interest was drawn with.. View More»
  DOI: 10.4172/2167-0889.1000170

  Abstract PDF