Molecular and Genetic Medicine

Goswami A

Publications

• Short Communication
  A Possible Link between Dysregulated Mitochondrial Calcium Homeostasis and Citrullination in Rheumatoid Arthritis
  Author(s): Gautam S, Goswami A, Chaurasia P and Dada RGautam S, Goswami A, Chaurasia P and Dada R
  
  Rheumatoid arthritis (RA) is characterized by citrullination of peptides and proteins mediated by calciumdependent peptidyl arginine deiminase enzymes (PADs). Various mechanisms of intracellular and extracellular protein citrullination have been elucidated so far. Here, we highlight one more important possible mechanism that could lead to intracellular citrullination due to dysregulated mitochondrial Ca2+ homeostasis i.e., inability of mitochondrial uptake of Ca2+ during physiological signaling and triggering the generation of autoimmune disease. Spontaneous secretion of intracellular PAD may be the result of high cytosolic Ca2+ due to a disturbance in mitochondrial calcium homeostasis secondary to oxidative damage without any compromise to the cell membrane. Various environmental triggers like air pollutants also induce oxidative stress (OS) which may compromise the mitochondrial integr.. Read More»
  DOI: 10.4172/1747-0862.1000351

  Abstract PDF