Grigoriy Andrievsky
Ukraine
Research Article
Differences in Antioxidant/Protective Efficacy of Hydrated C60 Fullerene Nanostructures in Liver and Brain of Rats with Streptozotocin-Induced Diabetes
Author(s): Victor Nedzvetsky, Grigoriy Andrievsky, Tamar Chachibaia and Artem TykhomyrovVictor Nedzvetsky, Grigoriy Andrievsky, Tamar Chachibaia and Artem Tykhomyrov
Background: Diabetes mellitus causes damage to many vital organs, including brain and liver, mostly due to excessive free radical generation and development of oxidative stress. Some water-soluble forms of C60 fullerene and their hydrated nanostructures are proposed for prevention as well as treatment of various pathological conditions caused by oxidative stress.
Aim of the study: Assessment and comparison of antioxidant effects of hydrated C60 fullerene (C60HyFn) in brain and liver of rats with experimental streptozotocin (STZ)-induced hyperglycemia and evaluation of possible neuroprotective capacity of C60HyFn acting as potent agent to suppress reactive astrocytosis. Materials and methods: To induce hyperglycemia, male Wistar rats received single intraperitoneal (i.p.) injection of STZ in a dose of 45 mg/kg body weight (b.w). Thirty five rats were divided into 5 groups (7 ani.. View More»
