Cancer Science & Therapy

Hala Ahmed Zaghloul Isamil El Lathy

Publications

• Research Article
  The Pretreatment Tumor Infiltrating T Lymphocytes (CD8⁺, CD4⁺, FOXP3⁺) and Systemic Neutrophil-Lymphocytes Ratio in Definitively Treated Cervical Cancer Patients: The Correlation to Clinicopathological Factors and Survival
  Author(s): Hala Ahmed Zaghloul Isamil El Lathy, Ahlam Dohal and Miral MashhourHala Ahmed Zaghloul Isamil El Lathy, Ahlam Dohal and Miral Mashhour
  
  Purpose: To link pretreatment tumor infiltrating T-lymphocytes (TILs) (CD8+, CD4+, FOXP3+) and systemic neutrophil to lymphocyte ratio (NLR) to different clinical/pathological elements. Consequently, emphasizing their impact in predicting the outcome in definitively treated cervical cancer patients. Methods: The most relevant clinical/pathological factors were used to establish a link with pre-treatment NLR and densities of TILs (CD8+, CD4+, FOXP3+) in cervical biopsies. The predictive significance of pre-treatment TILs and NLR, both for disease free survival (DFS) and overall survival (OS) were evaluated using Log rank alongside Cox regression analysis. Results: Radical hysterectomies followed by adjuvant radiation with or without chemotherapy were offered to 28 patients, while the remaining twenty eligible patients r.. Read More»
  DOI: 10.4172/1948-5956.1000528

  Abstract PDF