Lupus: Open Access
Open Access
ISSN: 2684-1630
+44 1300 500008
ISSN: 2684-1630
+44 1300 500008
Hans-Joachim Anders
University of Munich,
Munich
Germany
Review Article
Update on Immune Mechanisms in Systemic Lupus and Lupus Nephritis
Author(s): Satish Kumar Devarapu, Hans-Joachim Anders and Khader Valli RupanagudiSatish Kumar Devarapu, Hans-Joachim Anders and Khader Valli Rupanagudi
Lupus nephritis is a frequent complication of systemic lupus erythematosus. Multiple pathological mechanisms attribute to the pathogenesis of lupus nephritis. These mechanisms can be grossly divided into two groups, extrarenal or intrarenal pathways. A variety of genetic variants break immune tolerance to nuclear autoantigens, as evident from the existence of antinuclear antibodies. Furthermore, molecular mimicry of endogenous nucleic acids activating Toll-like receptors trigger antiviral immunity. In this review, we discuss the molecular pathomechanisms of lupus nephritis... View More»
DOI:
10.35248/2684-1630.16.1.116