Journal of Material Sciences & Engineering

Haruo Sugi

Publications

• Review Article
  Evidence for the Essential Role of Myosin Subfragment-2 in Muscle Contraction: Functional Communication between Myosin Head and Subfragment-2
  Author(s): Haruo SugiHaruo Sugi
  
  In 1971, Harrington et al. put forward a hypothesis, in which helix-coil transition in the hinge region of myosin subfragment-2 (S-2) contributes to muscle contraction. The helix-coil transition hypothesis has been, however, ignored by muscle investigators over many years. In 1992, we worked with him to examine the effect of polyclonal antibody to myosin subfragment-2 (anti-S-2 antibody), and found that the antibody eliminated Ca2+-activated isometric force generation of skinned vertebrate muscle fibers without affecting MgATPase activity. Further studies using the same antibody indicated functional communication between myosin head and myosin S-2, including regulation of binding strength between myosin head and actin filament during Ca2+-activated contraction in vertebrate muscle fibers. These findings indicate that the swinging lever arm hypothesis, in which muscle contraction resul.. Read More»
  DOI: 10.4172/2169-0022.1000386

  Abstract PDF