Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
+44 1223 790975
ISSN: 2155-9570
+44 1223 790975
Heloisa Helena Russ
Centro da Visão/ Hospital de Clinicas da Universidade Federal do Paraná,
Rua Paster, 26- Batel. Curitiba, Paraná, CEP 80250080
Brazil
Research Article
Clinical and Histologic Comparison of Conjunctival Changes Induced by Antiglaucoma Beta Blockers, Carbonic Anhydrase Inhibitors, Alfa Agonists and Fixed Combinations with and without Preservatives
Author(s): Heloisa Helena Russ, Amalia Turner-Gianicco, Fabiano Montiani-Ferreira and Leandro LimaHeloisa Helena Russ, Amalia Turner-Gianicco, Fabiano Montiani-Ferreira and Leandro Lima
Background: The objective of this research was to evaluate and compare clinical tests, histological and immunohistochemical changes induced by antiglaucoma beta blockers, carbonic anhydrase inhibitors, alfa agonists and fixed combinations containing benzalkonium chloride (BAK) and without preservative (BAKFREE) in the conjunctiva of rabbits. A total of 60 rabbits (120 eyes), were divided into six groups, and treated during 30 days with: dorzolamide 2%+timolol maleate 0.5% BAK, dorzolamide 2%+timolol maleate 0.5%BAKFREE, brinzolamide 1% +timolol maleate 0.5% BAK, brimonidine 0.2%+timolol maleate 0.5%BAK, timolol maleate 0.5%BAK and control solution BAK. Right eyes served as controls and received no medication. Corneal touch threshold (CTT), Schirmer tear test (STT) and intraocular pressure (IOP) were measured during pre and post treatme.. View More»
DOI:
10.4172/2155-9570.1000606