Journal of Developing Drugs
Open Access
ISSN: 2329-6631
+44 1478 350008
ISSN: 2329-6631
+44 1478 350008
Himankar Baishya
North Shi Zhen in the North Industrial area,
Shunyi District, Beijing
China
Research Article
Application of Mathematical Models in Drug Release Kinetics of Carbidopa and Levodopa ER Tablets
Author(s): Radhakant Gouda, Himankar Baishya and Zhao QingRadhakant Gouda, Himankar Baishya and Zhao Qing
The aim of present work is to determine and analyse the kinetics of drug release from the matrix tablet by employing various mathematical models. A study was done with Carbidopa and Levodopa ER tablets, 50 mg/200 mg by employing wet granulation technique using Hydroxypropyl methylcellulose and Hydroxypropyl cellulose as matrix forming polymer. The in-vitro drug release profile was carried out in 0.1 N HCl (900 mL) using USP dissolution apparatus II (Paddle) at 50 rpm at an extended time period of 0.5, 0.75, 1, 1.5, 2, 2.5, 3 and 4 hours. The drug release data was obtained, quantitatively correlated and interpreted with various mathematical models viz. Zero order model, first order model, Higuchi model, Hixson-Crowell model and Korsmeyer-Peppas model and evaluated to understand the kinetics of drug release. The criterion for the most suitable model was based on the high degree of coeff.. View More»
DOI:
10.4172/2329-6631.1000171