Journal of Depression and Anxiety
Open Access

Hua Zhang

Publications

• Research Article
  Disruption of Type I-IFN Signaling Decreases Autoimmune Development and Kidney Damage, But Not Anxiety-Like Behaviors in Lupus NZB Mice
  Author(s): Jianping Wang and Hua ZhangJianping Wang and Hua Zhang
  
  Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder that is accompanied by neuropsychiatric manifestations such as anxiety. Despite undefined etio-pathogenesis for SLE, emerging evidence supports the importance of type I interferon (IFN) in the pathogenesis of autoimmune formation and renal damage both in SLE patients and lupus mice. Linkage mapping identified a quantitative trait locus (QTL) for elevated plus-maze (EPM) performance on the segment of chromosome 4 in lupus-prone New Zealand black (NZB) mice where the type I IFN-α genes are harbored. To determine possible roles of type I IFNs for anxiety-like behaviors in NZB mice, we evaluated the anxiety profile by EPM test in NZB mice with deficiency of type I-IFN receptor (IFNARKO). Consistent with previous observation, disruption of the type I-IFN signaling resulted in a dramatic attenuation in glomerulone.. View More»
  DOI: 10.4172/2167-1044.1000271

  Abstract PDF

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