Journal of Blood Disorders & Transfusion

Huichun Zhan

Publications

• Research Article
  Thrombocytosis in Myelodysplastic Syndromes: Not an Innocent Bystander
  Author(s): Jennifer Zikria, Naomi Galili, Wei Yann Tsai, Huichun Zhan, Xiaomei Ma and Azra RazaJennifer Zikria, Naomi Galili, Wei Yann Tsai, Huichun Zhan, Xiaomei Ma and Azra Raza
  
  Background: Myelodysplastic Syndromes (MDS) are typically characterized by peripheral blood cytopenias. However, some MDS is associated with thrombocytosis rather than thrombocytopenia. The prognostic significance of thrombocytosis is unknown. The purpose of this study is to determine if thrombocytosis predicts Overall Survival (OS). Methods: We reviewed a prospective cohort of patients with myeloid disorders from 1994 to July 2011. The median duration of observation was 6.3 years. The cohort included 5,886 bone marrow biopsies or aspirates from 2,042 patients. OS of patients with thrombocytosis was compared to WHO case matched patients with normal (100-450,000) and low platelet counts (<100,000). All-cause mortality was evaluated using Cox proportional hazard regression modeling and Kaplan Meier methods. Results:.. View More»
  DOI: 10.4172/2155-9864.S3-002

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