Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
+44 1223 790975
ISSN: 2155-9570
+44 1223 790975
Hung-Chi Chen
People's Republic of China
Review Article
Corneal Neovascularization as a Target for Nucleotide-Based Therapies
Author(s): Yi-Jen Hsueh, Hung-Chi Chen, Jui-Yang Lai, Jan-Kan Chen and David Hui-Kang MaYi-Jen Hsueh, Hung-Chi Chen, Jui-Yang Lai, Jan-Kan Chen and David Hui-Kang Ma
The cornea is a transparent tissue with avascular characteristics (corneal avascularity). It can be compromised by imbalances of angiogenic factors due to chemical injuries, infections, or autoimmune diseases such as Stevens- Johnson’s syndrome, which can lead to corneal blindness. Clinically, the etiologies of corneal neovascularization (NV), such as inflammation, immune rejection, limbal stem cell deficiency, or hypoxia, are usually long-lasting; therefore, conventional treatment modalities, including antiangiogenic medications, laser, or surgeries have only a suboptimal effect, and the prognosis is even worse with multiple recurrences. In contrast, novel treatment modalities, such as gene therapy (enhanced intracellular expression of antiangiogenic factors) and nucleotide-based antiangiogenic therapy (antisense oligonucleotides, silence-RNA, and micro-RNA) have been accomplis.. View More»
DOI:
10.4172/2155-9570.1000409