Journal of Carcinogenesis & Mutagenesis

Ibrahim A Alsafari

Publications

• Research Article
  Nuclear Localisation of Autophagic p62 and Associated Cytoplasmic Beclin-1 and Bcl-2 Expressions in Adenomas and Adenocarcinomas of the Colorectal Regions
  Author(s): Ernest Adankwah, Kwabena Owusu Danquah, Daniel Gyamfi, Paul Poku Sampene Ossei, Emmanuel Asiamah, Ibrahim A Alsafari and Tony MadgwickErnest Adankwah, Kwabena Owusu Danquah, Daniel Gyamfi, Paul Poku Sampene Ossei, Emmanuel Asiamah, Ibrahim A Alsafari and Tony Madgwick
  
  Background: Autophagy is an important biological process that is involved in cellular homeostasis and survival. Derailment of some cellular autophagic processes affects normal cellular function, resulting in cancers and other disorders. Autophagy related proteins are Beclin-1, a human tumour suppressor, Bcl-2 and p62 have been characterised in most cancers. Particularly, a number of studies have reported a loss of Beclin-1 and up regulation of Bcl-2 and p62 in breast cancers. However, studies regarding the expression of these proteins in colorectal adenomaadenocarcinoma transformation sequence are yet to be described. In this study, we examined the expression patterns of Beclin-1, Bcl-2 and p62 in both colorectal adenomas and adenocarcinomas. Methods: Immunohistochemistry was performed on formalin-fixed paraffin.. View More»
  DOI: 10.4172/2157-2518.1000314

  Abstract PDF