Journal of Cytology & Histology

Ismail Seckin

Publications

• Research Article
  Caffeic Acid Phenethyl Ester Prevents Mesengial Cell Apoptosis by Suppressing p38MAPK Signal
  Author(s): Emine Mamal, Murat Basar, Hafize Uzun and Ismail SeckinEmine Mamal, Murat Basar, Hafize Uzun and Ismail Seckin
  
  Background: Nitric oxide (NO), synthesis from L-arginine by Nitric oxide synthesizes (NOS) at kidney mesangial cells and involved in functional kidney defects such as acute kidney failure, inflammatory nephritis, diabetic nephropathy. CAPE (Caffeic acid phenethyl ester) is natural antioxidant which has anti-inflammatory, anti-tumor affects. In this study we investigated effects of NO on rat kidney and therapeutic and protective effects of CAPE. Methods: We used albino Wistar rats, weigh 150-200. Our experimental groups: 1) Control 2) L-arginine-given group 3) Preventative group (L-arginine and CAPE administered together) 4) Therapeutic group (after L-arginine administration; CAPE administered 7 days) (n=10/per group). Kidney tissues harvested and cortex region divided into two in order to perform western blot and immunohistochemistry. p38MAPK and active caspase-3 levels investigated w.. Read More»
  DOI: 10.4172/2157-7099.1000155

  Abstract PDF