Clinical Pediatrics: Open Access
Open Access
ISSN: 2572-0775
ISSN: 2572-0775
Iva Topalušić
Croatia
Research Article
Association of Asthma Symptoms and Exacerbation with Inflammatory Biomarkers
Author(s): Marta Navratil, Irena Ivković Jureković, Iva Topalušić, Alen Švigir, Nataša Andrijašević and Filip RubićMarta Navratil, Irena Ivković Jureković, Iva Topalušić, Alen Švigir, Nataša Andrijašević and Filip Rubić
Objective: To investigate a relationship of asthma symptoms and exacerbations with systemic (high-sensitivity Creactive protein (hs-CRP), eosinophilic cationic protein (ECP), leukocytes) and local (exhaled NO (FENO), pH and urates in exhaled breath condensate (EBC) and exhaled breath temperature (EBT)) inflammatory biomarkers (BMs) in asthmatic children.
Methods: This cross-sectional study comprised 93 consecutive asthmatic patients (age 6-18 years, 22 girls) with mild intermittent asthma ((IA), N=44) and mild to moderate persistent asthma ((PA), N=49). Medical history (asthma symptoms and exacerbation), pulmonary function, FENO, EBT, samples of exhaled breath and peripheral blood were collected.
Results: Local BMs (EBC urates and EBT) showed stronger correlation with asthma symptoms then systemic BMs (hs-CRP, blood co.. View More»
DOI:
10.4172/2572-0775.1000122