Journal of Hematology & Thromboembolic Diseases
Open Access
ISSN: 2329-8790
+44 1478 350008
ISSN: 2329-8790
+44 1478 350008
Jan Jacques Michiels
University Hospital, Antwerp,
Wilrijkstraat 10, 2650 Edegem/Antwerp
Belgium
Research Article
Three Phenotypes of JAKV617F Mutated Essential Thrombocythemia and Early Thrombocythemic Stage of Polycythemia Vera in 10 Patients: Important to Differentiate because Natural History Differ
Author(s): Jan Jacques Michiels, Zwi Berneman, Wilfried Schroyens, Kirsten van Lom, Konnie Hebeda, King H. Lam and Hendrik De RaeveJan Jacques Michiels, Zwi Berneman, Wilfried Schroyens, Kirsten van Lom, Konnie Hebeda, King H. Lam and Hendrik De Raeve
In 10 JAK2V617F positive patients with early myeloproliferative essential thrombocythemia (ET) or polycythemia vera (PV) we sequentially used the Polycythemia Vera Study Group (PVSG), the Thrombocythemia Vera Study Group (TVSG) and the 2008 WHO criteria for the clinical diagnosis of essential thrombocythemia (ET) ad polycythemia vera (PV). Subsequently, we evaluated bone marrow features and laboratory and molecular markers including endogenous erythroid colony (EEC), serum erythropoietine (EPO) mutation for the classification of early MPD. Six symptomatic patients had a delayed diagnosis of slow onset latent (masked) ET and 4 patients presented with rapid onset PV associated with thrombocythemia. We could clearly distinguish three phenotypes of ET when the 2008 European clinical, molecular and pathological (2008 WHO-ECMP) criteria for ET and PV are applied. These include ET phenotype .. View More»
DOI:
10.4172/2329-8790.1000S1004