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Jichun Chen
Jichun Chen
Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health,
Bethesda, MD
Tanzania
Publications
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Short Communication
Hematopoietic Aging Biomarkers in Peromyscus leucopus Mice
Author(s): Zenghua Lin, Sachiko Kajigaya, Xingmin Feng, Jichun Chen and Neal S YoungZenghua Lin, Sachiko Kajigaya, Xingmin Feng, Jichun Chen and Neal S Young
We analyzed hematopoietic phenotypes in Peromyscus leucopus (PL) mice at young (2-9 months), middle (22-23 months) and old (33-46 months) ages aimed at characterizing age-associated changes in this unique rodent species. We found a significantly higher number of monocytes in old PL mice in peripheral blood, and higher proportions of CD44+ cells in blood, spleen and bone marrow in old PL mice than in middle and young counterparts. We conclude that elevated blood monocyte counts and up-regulated hematopoietic cell CD44 expression are two useful aging biomarkers for PL mice. .. View More»
DOI: 10.4172/2329-8847.1000169