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John Butler | OMICS International
ISSN: 2157-7099

Journal of Cytology & Histology
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John Butler


NAD(P)H:Quinone Oxidoreductase 1 Expression in Human Reproductive System and Mitomycin-C Cytotoxicity: A New Chapter for Old Compounds?

NAD(P)H:quinone oxidoreductase 1 (NQO1; DT-diaphorase; DTD) is a cytosolic two-electron reductase, and compounds of the family of quinones such as mitomycin C are efficiently bio-activated by this enzyme. The observation that DT-diaphorase is over-expressed in many cancerous tissues compared to normal tissues has provided us with a selective target... Read More»

Francesco Zappa, Timothy Ward, Ennio Pedrinis, John Butler and Alan McGown

Research Article: J Cytol Histol 2014, 5: 209

DOI: 10.4172/2157-7099.1000209

Abstract Peer-reviewed Full Article Peer-reviewed Article PDF Mobile Full Article