Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
+44 1300 500008
ISSN: 2155-9880
+44 1300 500008
John F. Keaney
Tanzania
Research Article
Plasma MicroRNAs Relate to Atrial Fibrillation Recurrence after Catheter Ablation: Longitudinal Findings from the MiRhythm Study
Author(s): Aditya Vaze, Kevin Donahue, Matthew Spring, Mayank Sardana, Kahraman Tanriverdi, Jane E. Freedman, John F. Keaney, Emelia J. Benjamin, Steven A. Lubitz MPH, Lawrence Rosenthal, Kevin Floyd and David D. McManusAditya Vaze, Kevin Donahue, Matthew Spring, Mayank Sardana, Kahraman Tanriverdi, Jane E. Freedman, John F. Keaney, Emelia J. Benjamin, Steven A. Lubitz MPH, Lawrence Rosenthal, Kevin Floyd and David D. McManus
Introduction: Genetic and transcriptomic factors play important roles as mediators of new-onset and recurrent atrial fibrillation (AF). MicroRNAs (miRNAs) regulate expression of gene networks involved in key aspects of atrial remodeling. Associations between circulating miRNAs and AF recurrence are unknown. We tested the hypothesis that cardiac miRNAs associated with electrical and structural remodeling predict recurrent AF rhythm in post-ablation patients.
Methods: We quantified plasma expression of 86 cardiac miRNAs using RT-qPCR in 83 consenting participants undergoing ablation for AF. MiRNA expression was re-measured 1-month post-ablation in a subset of 43 of 83 study participants. Then all 83 patients were followed over a 12-month period for AF recurrence and plasma miRNA expression was compared between baseline and 1-month post-ablatio.. View More»
DOI:
10.4172/2155-9880.1000502