Journal of Nutrition & Food Sciences
Open Access
ISSN: 2155-9600
ISSN: 2155-9600
Joseph Schragenheim
Tanzania
Research Article
Beneficial Effects Of Thymoquinone On Metabolic Function And Fatty Liver In A Murine Model Of Obesity
Author(s): Maria Licari, Marco Raffaele, Zachary F. Rosman, Joseph Schragenheim, Lars Bellner, Luca Vanella, Rita Rezzani, Luigi Rodella, Francesca Bonomini, Edith Hochhauser, Michael Arad and Nader G. AbrahamMaria Licari, Marco Raffaele, Zachary F. Rosman, Joseph Schragenheim, Lars Bellner, Luca Vanella, Rita Rezzani, Luigi Rodella, Francesca Bonomini, Edith Hochhauser, Michael Arad and Nader G. Abraham
Aim: Nigella sativa seeds contain a high amount of Thymoquinone (TQ), an antioxidant. We therefore hypothesized that Nigella sativa oil would, through the antioxidant properties of TQ ameliorate obesity-induced hyperglycemia and decrease blood pressure and OX-LDL in obese mice.
Methods: Commencing at eight weeks of age, C57B16 male mice were fed a high fat diet (HF) for 20 weeks. Mice were divided into three groups of five animals each as follows: group 1) Lean, group 2) HF diet, group 3) HF diet treated for the last 8 weeks with 3%TQ. Inflammatory biomarkers, antioxidant biomarkers, mitochondrial biogenesis and tissue fat accumulation and hepatic steatosis were determined.
Results: 3% TQ treatment resulted in an increase of oxygen consumption decreased fasting glucose and blood pressure (P<0.0.. View More»