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Josephine Drury
Josephine Drury
United Kingdom
Publications
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Research Article
Correlation of Plasma and Salivary Cortisol in Extremely Premature Infants
Author(s): Sze M Ng, Josephine Drury, Swathi Upradrasta, Michael Weindling and Mark A TurnerSze M Ng, Josephine Drury, Swathi Upradrasta, Michael Weindling and Mark A Turner
Background: In the neonatal period, cortisol concentrations are expected to increase during significant stress and are important for survival. Extreme preterm infants may develop adrenal insufficiency in the early neonatal period. Cortisol is 90% bound to cortisol binding globulins (CBG) in the circulation; therefore measurements of plasma cortisol can be compromised by conditions that alter CBG levels. Measurement of free cortisol is the best indicator of adrenal glucocorticoid secretion and can be determined in the saliva. Few studies have been reported on salivary cortisol determination in the neonatal period and particularly, extremely premature infants. Methods: There were 65 infants (36 males). Mean gestation 25.3 ± 1.3 weeks. We obtained early morning plasma and salivary cortisol sampling before day 5 of postnatal age from extr.. View More»
DOI: 10.4172/2167-0897.1000260