Kamal Kiran Mukkavali
India
Research Article
Exploration of Insertion/Deletion Polymorphism of Angiotensin Converting Enzyme in Post-Transplant Diabetes Mellitus Individuals from an Asian Indian Population
Author(s): Kiran Kumar Vattam, Imran Ali Khan, Subhadra Poornima, Kamal Kiran Mukkavali, Pragna Rao and Qurratulain HasanKiran Kumar Vattam, Imran Ali Khan, Subhadra Poornima, Kamal Kiran Mukkavali, Pragna Rao and Qurratulain Hasan
This work intended to test the association of Angiotensin Converting Enzyme (ACE) gene insertion (I) and Deletion (D) polymorphism in the End Stage Renal Disease (ESRD) subjects who developed post-transplant diabetes mellitus (PTDM) on using immunosuppressive drugs from an Asian Indian population. ACE is known to play an important role in the adaptation and regulation of systemic and renal circulations through angiogenesis II formation and kinins metabolism. A total of 240 non-diabetic ESRD individuals were prospectively screened for PTDM after renal transplant and 42 (30%) patients developed PTDM, whereas remaining 98 (70%) patients were non-PTDM. Genomic DNA was isolated from all the subjects and genotyping was performed for I28005D polymorphism using PCR-based assay. Individuals with PTDM had a higher DD (33.3%) genotypes and D (0.51) allele compared to controls. There was a signif.. View More»
