Journal of Alcoholism & Drug Dependence
Open Access
ISSN: 2329-6488
+44 1223 790975
ISSN: 2329-6488
+44 1223 790975
Kazuyuki Yoshizaki
The Institute of Scientific and Industrial Research,
8-1 Mihogaoka, Ibaraki, Osaka 567-0047
Japan
Short Communication
Mechanism and Clinical Significance of IL-6 Combined with TNF-α or IL-1 for the Induction of Acute Phase Proteins SAA and CRP in Chronic Inflammatory Diseases
Author(s): Soken-Nakazawa J Song and Kazuyuki YoshizakiSoken-Nakazawa J Song and Kazuyuki Yoshizaki
Serum amyloid A (SAA) and C-reactive protein (CRP) are two major acute phase proteins whose serum concentrations increase in response to inflammation, though the exact mechanism underlying this induction remains unknown. Dysregulated production of interleukin (IL)-6 plays a pathogenic role in various inflammatory diseases such as rheumatoid arthritis, Castleman’s disease and systemic juvenile idiopathic arthritis. IL-6 blocking therapy with an anti-IL-6 receptor antibody (tocilizumab) can ameliorate clinical symptoms and abnormal laboratory findings, and completely normalize CRP and SAA levels in rheumatoid arthritis patients. Conversely, therapy for blocking tumor necrosis factor (TNF)-α, another key pathogenic factor in rheumatoid arthritis, barely lowers CRP and SAA to within their normal range, suggesting that IL-6 and.. View More»
DOI:
10.4172/2329-6488.1000239