ISSN: 2155-9899
+44 1223 790975
Komarnicki Mieczyslaw
Poland
Case Report
IgG Monoclonal Immunoglobulin (M-protein) as Factor V Inhibitor in Multiple Myeloma Patient: Case Report and Discussion
Author(s): Lewandowski Krzysztof, Szczepaniak Tomasz, Dytfeld Dominik, Wojtasinska Ewelina, Dziatkiewicz Paulina, Przysiecka Lucja, Borowczyk Martyna, Poplawski Dariusz and Komarnicki MieczyslawLewandowski Krzysztof, Szczepaniak Tomasz, Dytfeld Dominik, Wojtasinska Ewelina, Dziatkiewicz Paulina, Przysiecka Lucja, Borowczyk Martyna, Poplawski Dariusz and Komarnicki Mieczyslaw
We present a case of a 53-year-old male with a symptomatic relapse of IgGλ multiple myeloma who was readmitted to the hospital with clinical symptoms of retroperitoneal hematoma. Laboratory tests revealed high concentration of monoclonal immunoglobulin G (32 g/l, 91.6% of total IgG) in the serum, prolongation of activated partial thromboplastin time (aPTT), prothrombin time (PT), and thrombin time (TT), significantly decreased factor V procoagulant activity and the presence of factor V inhibitor. After successful retreatment with the use of six cycles of bortezomib, adriamycin and dexamethasone, the monoclonal IgG concentration in the patient’s serum significantly decreased (up to 1.3 g/l). At that time, also the normalization of the results of aPTT, PT and TT was stated. Therefore, the presence of factor V inhibitor in monoclonal immunoglobulin fraction was suspected. To c.. View More»
DOI:
10.4172/2155-9899.1000410