Journal of Clinical & Experimental Pharmacology

Léa Shrivastava

Publications

• Research
  Clinical Efficacy of a Dual Action, Topical Anti-edematous and Antiinflammatory Device for the Treatment of External Hemorrhoids
  Author(s): Léa Shrivastava, Gisela da Silva Borges and Ravi ShrivastavaLéa Shrivastava, Gisela da Silva Borges and Ravi Shrivastava
  
  Objective: External hemorrhoids are enlarged, bulging blood vessels in and around the anus and lower rectum. They associate several pathologies such as engorged, edematous and inflamed sinusoids, with numerous proinflammatory cytokines on their surface, requiring a multi-target therapeutic approach. In the absence of any effective treatment, we assessed a newly conceived osmotically active, hypertonic, filmogen solution (Pileseptine-e) directed at attracting hypotonic liquid and helping suppress inflammation. The clinical efficacy and safety of Pileseptine-e on external hemorrhoids was evaluated in this study. Methods: A 2-week treatment + 1-week follow-up, comparative, randomized, double blind, clinical trial with Pileseptine-e (n=37, test product) versus saline spray (n=17, placebo) was performed in patients suffering from external hemorrhoid.. View More»
  DOI: 10.4172/2161-1459.1000246

  Abstract PDF