Organic Chemistry: Current Research
Open Access
ISSN: 2161-0401
+44 1478 350008
ISSN: 2161-0401
+44 1478 350008
Lei Fu
School of Pharmacy,
No. 800 Dongchuan Rd, Shanghai 200240
Indiana
Research Article
Synthesis and Antibacterial Activity Study of C-3 α, β-Unsaturated Ketone Linked Benzofuran Derivatives
Author(s): Wenlu Liu, Xizhen Jiang, Wei Zhang, Faqin Jiang and Lei FuWenlu Liu, Xizhen Jiang, Wei Zhang, Faqin Jiang and Lei Fu
Based on a benzofuran skeleton bearing aryl substituent at its C-3 position through an α, β-unsaturated ketone linker, twenty-one new compounds were chemically synthesized and biologically evaluated for their antibacterial activities against four bacteria, Escherichia coli, Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus, and Bacillus subtilis. Nine of the synthesized benzofuran derivatives exhibited antibacterial activities. Among them, compound 7e showed excellent MIC80 values from 0.78 to 1.56 μg/mL and was comparable to the positive control drugs.
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DOI:
10.4172/2161-0401.1000164