Journal of Hypertension: Open Access

Lei Han

Publications

• Research Article
  Effects of Phosphodiesterase Type 5 (PDE-5) Inhibitors in the Management of Pulmonary Arterial Hypertension: A Systematic Review and Meta-analysis Pointing on Peak VO2
  Author(s): Rutahoile WM, David NM, Angela AP, Abdallah ZH, Xiao Li Zhou, Huang Wei and Lei HanRutahoile WM, David NM, Angela AP, Abdallah ZH, Xiao Li Zhou, Huang Wei and Lei Han
  
  Background: In settings where new drugs for pulmonary arterial hypertension (PAH) are not possible due to lack of availability and cost; PDE-5 inhibitors such as sildenafil is the drug of choice in the management of PAH. In this study we performed a meta-analysis to evaluate the effects of oral sildenafil in PAH, pointing on peak VO2 improvement. Methods: We retrieved randomized controlled trials (RCTs) of the effects of PDE-5 inhibitors, sildenafil in patients with PAH using PubMed, Medline, Embase, Cochrane Library, Google scholar and manual search from 2011 to 2016. Random controlled trials that compared oral sildenafil with placebo were selected. Data for populations, interventions, and outcomes were extracted independently by 2 investigators, and disagreements were resolved by consensus. Quality assessment was performed using t.. Read More»
  DOI: 10.4172/2167-1095.1000237

  Abstract PDF