Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Luis A Diaz
Department of Dermatology, CB# 7287,
NC 27599
Tanzania
Research Article
Analysis of Anti-desmoglein 1 Autoantibodies in 68 Healthy Mother/Neonate Pairs from a Highly Endemic Region of Fogo Selvagem in Brazil
Author(s): Julio Hilario-Vargas, Irineu B Vitorio, Christopher Stamey, Donna A Culton, Phillip Prisayanh, Evandro A Rivitti, Valeria Aoki, Gunter Hans Filho, Vandir dos Santos, Bahjat Qaqish and Luis A DiazJulio Hilario-Vargas, Irineu B Vitorio, Christopher Stamey, Donna A Culton, Phillip Prisayanh, Evandro A Rivitti, Valeria Aoki, Gunter Hans Filho, Vandir dos Santos, Bahjat Qaqish and Luis A Diaz
Objectives: Fogo Selvagem (FS) in Limao Verde (LV), Brazil shows clinical and histological features of pemphigus foliaceus (PF) and shares pathogenic IgG4 anti-desmoglein 1 (Dsg1) autoantibodies. Previously, our group reported that mothers with active FS deliver babies with normal skin and low/negative titers of IgG4 autoantibodies by indirect immunofluorescence. It was postulated that maternal pathogenic IgG4 autoantibodies do not cross the placenta due to differential receptor mediated transplacental passage of IgG subclasses. It was also thought that placental Dsg1 may immunoadsorb pathogenic autoantibodies from the mother; hence pathogenic IgG4 autoantibodies do not reach the baby.
In this study we use a Dsg1-specific ELISA to test anti-Dsg1 autoantibodies of the IgM, IgG and the IgG subclasses in t.. View More»
DOI:
10.4172/2155-9554.1000209