Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
+44 1300 500008
ISSN: 2155-9880
+44 1300 500008
Mardi Gomberg-Maitland
Inova Heart and Vascular Institute,
3300 Gallows Road, Falls Church, VA 22042
Tanzania
Research Article
A Serial NT-proBNP Model to Improve Prognostication in Patients with Pulmonary Arterial Hypertension
Author(s): Aaron M Wolfson, Michael L Maitland, Vasiliki Thomeas, Cherylanne Glassner and Mardi Gomberg-MaitlandAaron M Wolfson, Michael L Maitland, Vasiliki Thomeas, Cherylanne Glassner and Mardi Gomberg-Maitland
Background: Baseline elevation in N-terminal pro-brain natriuretic peptide (NT-proBNP) in pulmonary arterial hypertension (PAH) patients is associated with worse outcomes. Serial measurement of commonly available biomarkers could improve the precision of prognostic estimates and our understanding of PAH pathophysiology.
Methods: Included were 103 PAH patients with baseline elevated NT-proBNP prior to the initiation or escalation of therapy with at least two subsequent NT-proBNP measurements. Using patients’ serial measurements, a linear mixed-effects model extrapolated a baseline NT-proBNP (intercept) and evolution (slope). These model-determined values were then used in Cox proportional hazards analysis to determine predictors of survival. Time-dependent area under the curve (AUC) analysis compared survival discrimination of serial versu.. View More»
DOI:
10.4172/2155-9880.1000555