Maria Anagnostouli
Medical School of National and Kapodistrian University of Athens,
Aeginition Hospital, Athens
Greece
Review Article
HLA-Genotype in Multiple Sclerosis: The Role in Disease Onset, Clinical Course, Cognitive Status and Response to Treatment: A Clear Step Towards Personalized Therapeutics
Author(s): Petros Stamatelos and Maria AnagnostouliPetros Stamatelos and Maria Anagnostouli
Multiple Sclerosis (MS) is probably the best studied chronic inflammatory and demyelinating disease of the Central Nervous System (CNS), with a clear impact on patients’ quality of life. Many factors have been described to play a role in the initiation and clinical course of the disease, as well as in the response to medication. These factors include age at onset, gender, viral infections, Human Leucocyte Antigen (HLA)-genotype, non-HLA genes, Vitamin D levels and smoking. HLA genetic profile is the most important one, as it not only influences every aspect of the disease, but it also modifies the effect of the other factors.
In this review article we summarize the decisive effect of HLA-genotype on MS initiation, clinical course, cognitive impairment and therapeutically outcome, as well as on other demyelinating diseases of the CNS (including Neuromyelitis Optica and .. View More»