England
Case Report
Tenogenesis of Equine Peripheral Blood-Derived Mesenchymal Stem Cells: In vitro Versus In vivo
Author(s): Sarah Broeckx, Marieke Zimmerman, Désirée Aerts, Bert Seys, Marc Suls, Tom Mariën and Jan H SpaasSarah Broeckx, Marieke Zimmerman, Désirée Aerts, Bert Seys, Marc Suls, Tom Mariën and Jan H Spaas
Background: Tendon injuries are a major cause of orthopaedic injuries, and often compromise the return to the same performance level. Therefore, different regenerative therapies, such as Mesenchymal Stem Cells (MSCs) and Platelet-rich Plasma (PRP) have been explored to improve tendon healing in horses. However, ectopic bone formation of undifferentiated cells is a major concern, because of reports of this phenomenon, after intralesional injections of MSCs in rabbit Achilles tendons. Methods: After MSC and PRP isolation of the Peripheral Blood (PB) of a donor horse, tenogenic induction of the MSCs (Tendo-Cell®) was confirmed through morphological changes and immunohistochemistry stainings. Secondly, the safety and clinical effects (ultrasound imaging) of Tendo-Cell®, in combination with PRP, was evaluated after a single intralesional injection in the lateral edge of the Super.. Read More»
DOI:
10.4172/2157-7552.S11-001
Journal of Tissue Science and Engineering received 807 citations as per Google Scholar report