Lupus: Open Access
Open Access
ISSN: 2684-1630
+44 1300 500008
ISSN: 2684-1630
+44 1300 500008
Marina I. Arleevskaya
Central Research Laboratory, Kazan State Medical Academy,
Serbia
Research Article
A Possible Interconnection of Cholesterol Overloading and Phagocytic Activityof the Monocytes in the Prone to Rheumatoid Arthritis Individuals
Author(s): Marina I. Arleevskaya, Aleksey Zabotin, Aida Gabdoulkhakova, Julia Filina and Anatoly TsibulkinMarina I. Arleevskaya, Aleksey Zabotin, Aida Gabdoulkhakova, Julia Filina and Anatoly Tsibulkin
Background: The abnormalities of lipid metabolism were demonstrated in the individuals, who later develop rheumatoid arthritis (RA). Trivial infections are known to contribute to atherosclerosis. We showed that first degree relatives of RA patients suffer from frequent and lingering trivial infections. The interconnection between the disturbance of lipid metabolism and the increased trivial infection burden is hypothesized in this group. Mononuclear phagocytes (MP) are the important players in RA pathogenesis, antiinfectious defense and atherosclerosis. The aim was to investigate the interconnection between the involvement of MPs in cholesterol metabolism, their phagocytic activity and the burden of trivial infections in the RA patients, their relatives and healthy individuals without autoimmune diseases in family history.
Methods: The followin.. View More»
DOI:
10.35248/2684-1630.16.1.112