Masami Tanaka
Metabolism, and Nephrology, School of Medicine,
35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582
Japan
Research Article
Hyperhomocysteinemia and Hyperuricemia are Closely Associated with a Decline in Renal Function in Patients with Type 2 Diabetes
Author(s): Masami Tanaka, Takeshi Nishimura and Hiroshi ItohMasami Tanaka, Takeshi Nishimura and Hiroshi Itoh
Objective: This study examined the association of homocysteine and uric acid with estimated glomerular filtration rate (eGFR) and explored their pathophysiological significance in patients with type 2 diabetes mellitus.
Methods: We performed a cross-sectional study in 56 Japanese patients with type 2 diabetes. The correlations of serum total homocysteine level with age, diabetes duration, HbA1c, body mass index, systolic blood pressure, eGFR, urinary albumin-to-creatine ratio (ACR), and uric acid were investigated. The correlation between eGFR and uric acid was also investigated. Serum total homocysteine level was compared in men and women, as well as in patients with and without diabetic nephropathy, hypertension, smoking, and alcohol consumption. Stepwise multiple regression analyses were performed to identify explanatory factors for eGFR,.. View More»
