Current Synthetic and Systems Biology
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Md. Mehedi Hasan

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  Computational Modeling of Lysine Post-Translational Modification: An Overview
  Author(s): Md. Mehedi Hasan , Mst. Shamima Khatun, and Hiroyuki Kurata Md. Mehedi Hasan , Mst. Shamima Khatun, and Hiroyuki Kurata
  
  Living organisms have a magnificent ordered and complex structure. In regulating the cellular functions, post-translational modifications (PTMs) are critical molecular measures. They alter protein conformation, modulating their activity, stability and localization. Up to date, more than 300 types of PTMs are experimentally discovered in vivo and in vitro pathways [1,2]. Major and common PTMs are methylation, ubiquitination, succinylation, phosphorylation, glycosylation, acetylation, and sumoylation. PTM is a biological mechanism common to both prokaryotic and eukaryotic organisms, which controls the protein functions and stability or the proteolytic cleavage of regulatory subunits and affects all aspects of cellular life. The PTM of a protein can also determine the cell signaling state, turnover, localization, and interactions with other proteins [3]. Therefore, the analysis of protei.. View More»
  DOI: 10.4172/2332-0737.1000137

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