Rheumatology: Current Research
Open Access
ISSN: 2161-1149 (Printed)
+44-20-4587-4809
ISSN: 2161-1149 (Printed)
+44-20-4587-4809
Melanie Cisewski
Germany
Research Article
Characterisation of the Inflammatory Infiltrate in Deep Lesions of Localized Scleroderma Compared to Erythema Nodosum
Author(s): Thilo Gambichler, Sarah Terras, Melanie Cisewski, Markus Stücker, Falk G. Bechara and Alexander KreuterThilo Gambichler, Sarah Terras, Melanie Cisewski, Markus Stücker, Falk G. Bechara and Alexander Kreuter
Background: Involvement of deep structures, predominantly the subcutis, may occur in many subtypes of localized scleroderma (LS).
Objectives: The purpose of the present study was to characterize the inflammatory infiltrate in deep lesions of LS (DLLS) with affection of the subcutaneous fat tissue, and to compare the findings with erythema nodosum (EN).
Methods: We assessed 22 patients with DLLS lesions who predominantly suffered from limited (n=8), generalized (n=8), linear (n=4), or deep (n=2) LS. Moreover, we studied 20 patients with EN. In each patient, a spindle-shaped full thickness skin excision was performed before the initiation of any antiphlogistic or immunosuppressive treatment. Biopsy specimens were processed for routine histology and immunohistochemistry for CD3, CD4, CD8, CD20, CD15, and CD68.
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DOI:
10.4172/2161-1149.1000141