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Min Chen | OMICS International
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

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Min Chen


Promotion of Caspase Activation by Caspase-9-mediated Feedback Amplification of Mitochondrial Damage

Mitochondrial disruption during apoptosis results in the activation of caspase-9 and a downstream caspase cascade. Triggering this caspase cascade leads to the cleavage of anti-apoptotic Bcl-2 family proteins, resulting in feedback amplification of mitochondrial disruption. However, whether such a feedback loop plays an important role in the promot... Read More»

Alan D. Guerrero, Ingo Schmitz, Min Chen and Jin Wang

Research Article: J Clin Cell Immunol 2012, 3:126

DOI: 10.4172/2155-9899.1000126

Abstract Peer-reviewed Full Article Peer-reviewed Article PDF