Journal of Clinical & Medical Genomics

Nagao M

Publications

• Research Article
  Meta-Analysis of Interleukin Polymorphisms and NSAID Usage Indicates Correlations to the Risk of Developing Cancer
  Author(s): Nagao M, Sato Y and Yamauchi ANagao M, Sato Y and Yamauchi A
  
  Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) is correlated to reduced risk of developing cancer through reduction of inflammation, which is an important risk factor for cancer. Several studies have investigated the possible association between polymorphisms in the gene encoding inflammatory cytokines and use of NSAIDs with cancer risk; however, these studies have obtained mixed results. Therefore, we performed a meta-analysis to evaluate the association between genetic polymorphisms of Interleukin (IL) 1B, IL6, IL8, and IL10, and NSAID usage with respect to cancer risk. We conducted a comprehensive search in PubMed through May 2013. Odds Ratios (ORs) with corresponding 95% Confidence Intervals (CIs) were calculated using the fixed-effect or the random-effect model. Comprehensive search of databases revealed eight studies fulfilling the inclusion criteria. Fo.. Read More»
  DOI: 10.4172/2332-0672.1000113

  Abstract PDF