Journal of Allergy & Therapy

Naohito Hato

Publications

• Research Article
  Suppressive Effect of a Thioamide-Related Compound SH-2251 on a Murine Allergic Rhinitis Model
  Author(s): Takashi Kitani, Saho Maruyama, Kunihide Aoishi, Naoya Nishida, Hideo Ogawa, Yasunori Abe, Yuji Hayashi, Masakatsu Yamashita and Naohito HatoTakashi Kitani, Saho Maruyama, Kunihide Aoishi, Naoya Nishida, Hideo Ogawa, Yasunori Abe, Yuji Hayashi, Masakatsu Yamashita and Naohito Hato
  
  Background: SH-2251 inhibits IL-5 production and type2 airway inflammation in a murine bronchial asthma model. However, the therapeutic effect of SH-2251 on allergic rhinitis (AR) has not been tested. We investigated whether or not SH-2251 could improve the nasal symptoms and inflammation in the nasal mucosa of a murine model of AR. Methods: AR was induced via intraperitoneal injection of ovalbumin (OVA) followed by daily intranasal challenge with OVA. SH-2251 (10 mg/kg) or vehicle (DMSO+Tween80) was administered orally once a day in the same period as the nasal challenge. Nasal symptoms were evaluated by counting the number of sneezing and nasal rubbing events on days 14, 17, 21, 28 and 35. On day 35, the levels of Il4, Il5, Il13, Ifnγ and Il1rl1 mRNA in the nasal mucosa were examined. The histological findings were examined on day 36... View More»
  DOI: 10.4172/2155-6121.1000267

  Abstract PDF