Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
+44 1223 790975
ISSN: 2155-9899
+44 1223 790975
Nicodemus T Tedla
Inflammation and Infection Research Centre, Faculty of Medicine,
Sydney, NSW 2052
Australia
Research Article
Hypersensitivity Pneumonitis Caused by House Cricket, Acheta domesticus
Author(s): Mijeong Park, Emma L Boys, Max Yan, Katherine Bryant, Barbara Cameron, Anup Desai, Paul S Thomas and Nicodemus T TedlaMijeong Park, Emma L Boys, Max Yan, Katherine Bryant, Barbara Cameron, Anup Desai, Paul S Thomas and Nicodemus T Tedla
Hypersensitivity pneumonitis (HP) is characterized by extensive interstitial lung inflammation primarily driven by activated T lymphocytes in response to exogenous antigens. The purpose of this study was to investigate whether chronic exposure to Acheta domesticus commonly known as house cricket was the underlying cause of HP in a 63 year old patient. HP was diagnosed by the history, spirometry high resolution computed tomography (HRCT) of the chest, bronchoalveolar lavage and trans-bronchial biopsy. Ouchterlony double diffusion assay, direct ELISA and Western blotting were used to detect immuno-reactive precipitins/antigens and anti-cricket antibodies. Mass spectrometry was used to identify the major putative antigens. T cell-mediated response to cricket antigens was assessed by in vitro cytokine production assays. HRCT showed extensive bilateral and ground glass op.. View More»
DOI:
10.4172/2155-9899.1000248