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Dr. Niewold studies the pathogenesis of human autoimmune diseases, such as lupus (systemic lupus erythematosus), rheumatoid arthritis, multiple sclerosis, sarcoidosis, and dermatomyositis. Dr. Niewold's laboratory is mapping the genetic factors that cause autoimmune diseases, and exploring the ways in which genetic variations alter the human immune response to result in disease. In lupus, he has established a large body of work demonstrating ways in which the normal immune response against viruses has been pathologically and persistently activated, resulting in autoimmune disease. Dr. Niewold also studies the different patterns of immune system activation that exist between people with the same autoimmune disease, as this should explain some of the heterogeneity in treatment responses we observe in autoimmunity.
Genetic studies, autoimmune diseases