Omar Faruque
Physiology & Molecular Biology, 125/1 Darus Salam, Mirpur-1, Dhaka
Bangladesh
Research Article
Association of Circulating Fasting TNF-A with Hyperglycemia is Stronger than with Body Mass Index in Newly Diagnosed Bangladeshi Type 2 Diabetic Subjects
Author(s): Omar Faruque, Shahangir Biswas, Syed M Kamaluddin, Muhammad Saiedullah, Motiar Rahman, Amirul Islam and Liaquat AliOmar Faruque, Shahangir Biswas, Syed M Kamaluddin, Muhammad Saiedullah, Motiar Rahman, Amirul Islam and Liaquat Ali
Background and aim: Insulin resistance and hypo-insulinemia are the major problems in Type 2 Diabetes Mellitus (T2DM). Epidemiological evidences suggest that obesity is linked with insulin resistance. Inflammatory cytokines such as TNF-α has also been associated with obesity and insulin resistance. The present study aims to evaluate fasting serum TNF-α in newly diagnosed type 2 diabetic subjects in different BMI group to observe its association with insulin sensitivity and obesity.
Methods: A total number of 145 newly diagnosed T2DM subjects were recruited in this study. On a prescheduled morning fasting and postprandial (2hrs after 75g glucose load) blood was drawn. Serum glucose was measured by glucose-oxidase method, lipid profile by enzymatic end-point method, insulin and TNF-α by ELISA methods. Insulin secretory capaci.. View More»
