Journal of Drug Metabolism & Toxicology
Open Access
ISSN: 2157-7609
+44-20-4587-4809
ISSN: 2157-7609
+44-20-4587-4809
Osano KO
P.O Box 43844-00100, Nairobi
Kenya
Research Article
Evaluation of In Vivo Toxicity of Dichloromethane: Methanolic Leaf Extracts of Prosopis juliflora in Female Wistar Albino Rats
Author(s): Osano KO, Nyamai DW, Ogola PE, Ouko RO, Arika WM, Bina MW, Mburu DN and Ngugi MPOsano KO, Nyamai DW, Ogola PE, Ouko RO, Arika WM, Bina MW, Mburu DN and Ngugi MP
Prosopis juliflora (Mathenge) is an exotic, evergreen leguminous lant found in the dry Coastal, Rift Valley and Northern parts of Kenya. It is tolerant to extreme environmental conditions, rated among top 100 most invasive species worldwide. The species leaf extracts is used in folk cure to various ailments and have promising pharmacological properties however; information on their toxicity in animals and human is insufficient. The study assessed phytochemical composition of P. juliflora leaf extracts, effects on body weights, organ weights, hematological parameters, liver function markers and histopathology in major organs of Wistar albino rats. Acute toxicity test was carried out at 2000 mg/kg body weight followed by a 28 days sub chronic toxicity study at 100, 350 and 1000 mg/kg body weight extracts dosages. The control animals were administered with normal saline. Animals were monito.. View More»
DOI:
10.4172/2157-7609.1000200